Laboratory for phospholipid research Publications
- Werner, Julia; Umstätter, Florian; Hertlein, Tobias; Beijer, Barbro; Kleist, Christian; Mühlberg, Eric; Zimmermann, Stefan; Haberkorn, Uwe; Ohlsen, Knut; Fricker, Gert; Mier, Walter; Uhl, Philipp: Improved pharmacokinetics and enhanced efficacy of the vancomycin derivative FU002 using a liposomal nanocarrier / Julia Werner, MSc, Florian Umstätter, PhD, Tobias Hertlein, PhD, Barbro Beijer, PhD, Christian Kleis… , February 2024. - 8 S. : Illustrationen
In: Nanomedicine, ISSN 1549-9642. 56(2024) vom: Feb., Artikel-ID 102731, Seite 1-8
DOI: 10.1016/j.nano.2023.102731 - Werner, Julia; Umstätter, Florian; Hertlein, Tobias; Mühlberg, Eric; Beijer, Barbro; Wohlfart, Sabrina; Zimmermann, Stefan; Haberkorn, Uwe; Ohlsen, Knut; Fricker, Gert; Mier, Walter; Uhl, Philipp: Oral delivery of the vancomycin derivative FU002 by a surface-modified liposomal nanocarrier / Julia Werner, Florian Umstätter, Tobias Hertlein, Eric Mühlberg, Barbro Beijer, Sabrina Wohlfart, St… , June 1, 2024. - 11 S. : Illustrationen
In: Advanced healthcare materials, ISSN 2192-2659. 13(2024), 14 vom: Juli, Artikel-ID 2303654, Seite 1-11
DOI: 10.1002/adhm.202303654 - Hammer, Maximilian; Herth, Jonathan; Muuss, Marcel; Schickhardt, Sonja; Scheuerle, Alexander F.; Khoramnia, Ramin; Łabuz, Grzegorz; Uhl, Philipp; Auffarth, Gerd U.: Forward light scattering of first to third generation vitreous body replacement hydrogels after surgical application compared to conventional silicone oils and vitreous body / Maximilian Hammer, Jonathan Herth, Marcel Muuss, Sonja Schickhardt, Alexander Scheuerle, Ramin Khora… , 21 October 2023. - 13 S.
In: Gels, ISSN 2310-2861. 9(2023), 10, Artikel-ID 837, Seite 1-13
DOI: 10.3390/gels9100837 - Hartl, Natascha Verena; Gabold, Bettina; Uhl, Philipp; Kromer, Adrian; Xiao, Ximian; Fricker, Gert; Mier, Walter; Liu, Runhui; Merkel, Olivia: ApoE-functionalization of nanoparticles for targeted brain delivery : a feasible method for polyplexes? / Natascha Hartl, Bettina Gabold, Philipp Uhl, Adrian Kromer, Ximian Xiao, Gert Fricker, Walter Mier, … , 12 December 2023. - 18 S.
In: Drug Delivery and Translational Research, ISSN 2190-3948. 14(2024), 6, Seite 1660-1677
DOI: 10.1007/s13346-023-01482-w - Hartl, Natascha Verena; Gabold, Bettina; Adams, Friederike; Uhl, Philipp; Oerter, Sabrina; Gätzner, Sabine; Metzger, Marco; König, Ann-Christine; Hauck, Stefanie M.; Appelt-Menzel, Antje; Mier, Walter; Fricker, Gert; Merkel, Olivia: Overcoming the blood-brain barrier? : Prediction of blood-brain permeability of hydrophobically modified polyethylenimine polyplexes for siRNA delivery into the brain with in vitro and in vivo models / Natascha Hartl, Bettina Gabold, Friederike Adams, Philipp Uhl, Sabrina Oerter, Sabine Gätzner, Marco… , 15 July 2023. - 17 S.
In: Journal of controlled release, ISSN 1873-4995. 360(2023), Seite 613-629
DOI: 10.1016/j.jconrel.2023.07.019 - Hammer, Maximilian; Schickhardt, Sonja; Merz, Patrick; Khoramnia, Ramin; Scheuerle, Alexander F.; Mier, Walter; Uhl, Philipp; Auffarth, Gerd U.: Intravitreal application : physicochemical properties of drugs dissolved in silicone oils of different density in comparison to the porcine vitreous body / Maximilian Hammer, Sonja K. Schickhardt, Patrick R. Merz, Ramin Khoramnia, Alexander F. Scheuerle, W… , 28 June 2022. - 11 S.
In: Pharmaceutics, ISSN 1999-4923. 14(2022), 7, Artikel-ID 1364, Seite 1-11
DOI: 10.3390/pharmaceutics14071364 - Pander, Giulia; Uhl, Philipp; Kühl, Nikos; Haberkorn, Uwe; Anderl, Jan; Mier, Walter: Antibody-drug conjugates : what drives their progress? / Giulia Pander, Philipp Uhl, Nikos Kühl, Uwe Haberkorn, Jan Anderl, Walter Mier, [October 2022]. - 10 S. : Illustrationen
In: Drug discovery today, ISSN 1878-5832. 27(2022), 10 vom: Okt., Artikel-ID 103311, Seite 1-10
DOI: 10.1016/j.drudis.2022.06.011 - Umstätter, Florian; Werner, Julia; Zerlin, Leah; Mühlberg, Eric; Kleist, Christian; Klika, Karel D.; Hertlein, Tobias; Beijer, Barbro; Domhan, Cornelius; Zimmermann, Stefan; Ohlsen, Knut; Haberkorn, Uwe; Mier, Walter; Uhl, Philipp: Impact of linker modification and PEGylation of vancomycin conjugates on structure-activity relationships and pharmacokinetics / Florian Umstätter, Julia Werner, Leah Zerlin, Eric Mühlberg, Christian Kleist, Karel D. Klika, Tobia… , 28 January 2022. - 14 S.
In: Pharmaceuticals, ISSN 1424-8247. 15(2022), 2, Artikel-ID 159, Seite 1-14
DOI: 10.3390/ph15020159 - Benzel, Julia; Bajraktari-Sylejmani, Gzona; Uhl, Philipp; Davis, Abigail; Nair, Sreenath; Pfister, Stefan; Haefeli, Walter E.; Weiß, Johanna; Burhenne, Jürgen; Pajtler, Kristian Wilfried; Sauter, Max: Investigating the central nervous system disposition of actinomycin D : implementation and evaluation of cerebral microdialysis and brain tissue measurements supported by UPLC-MS/MS quantification / Julia Benzel, Gzona Bajraktari-Sylejmani, Philipp Uhl, Abigail Davis, Sreenath Nair, Stefan M. Pfist… , 17 September 2021. - 16 S.
In: Pharmaceutics, ISSN 1999-4923. 13(2021), 9, special issue, Artikel-ID 1498, Seite 1-16
DOI: 10.3390/pharmaceutics13091498 - Pratsinis, Anna; Uhl, Philipp; Bolten, Jan Stephan; Hauswirth, Patrick; Schenk, Susanne Heidi; Urban, Stephan; Mier, Walter; Witzigmann, Dominik; Huwyler, Jörg: Virus-derived peptides for hepatic enzyme delivery / Anna Pratsinis, Philipp Uhl, Jan Stephan Bolten, Patrick Hauswirth, Susanne Heidi Schenk, Stephan Ur… , April 12, 2021. - 11 S.
In: Molecular pharmaceutics, ISSN 1543-8392. 18(2021), 5, Seite 2004-2014
DOI: 10.1021/acs.molpharmaceut.0c01222 - Sauter, Max; Uhl, Philipp; Burhenne, Jürgen; Haefeli, Walter E.: Application of triple quadrupole tandem mass spectrometry to the bioanalysis of collision-induced dissociation-resistant cyclic peptides : ultra-sensitive quantification of the somatostatin-analog pasireotide utilizing UHPLC-MS/MS / Max Sauter, Philipp Uhl, Jürgen Burhenne, Walter E. Haefeli, 2021
In: Journal of pharmaceutical and biomedical analysis, ISSN 1873-264X. 194(2021) Artikel-Nummer 113728, 7 Seiten
DOI: 10.1016/j.jpba.2020.113728 - Uhl, Philipp; Sauter, Max; Hertlein, Tobias; Witzigmann, Dominik; Laffleur, Flavia; Hofhaus, Götz; Fidelj, Veronika; Tursch, Anja; Özbek, Suat; Hopke, Elisa; Haberkorn, Uwe; Bernkop-Schnürch, Andreas; Ohlsen, Knut; Fricker, Gert; Mier, Walter: Overcoming the mucosal barrier : tetraether lipid-stabilized liposomal nanocarriers decorated with cell-penetrating peptides enable oral delivery of vancomycin / Philipp Uhl, Max Sauter, Tobias Hertlein, Dominik Witzigmann, Flavia Laffleur, Götz Hofhaus, Veronik… , 2021. - 12 S.
In: Advanced therapeutics, ISSN 2366-3987. 4(2021), 4, Artikel-ID 2000247, Seite 1-12
DOI: 10.1002/adtp.202000247 - Mühlberg, Eric; Umstätter, Florian; Domhan, Cornelius; Hertlein, Tobias; Ohlsen, Knut; Krause, Andreas; Kleist, Christian; Beijer, Barbro; Zimmermann, Stefan; Haberkorn, Uwe; Mier, Walter; Uhl, Philipp: Vancomycin-lipopeptide conjugates with high antimicrobial activity on vancomycin-resistant enterococci / Eric Mühlberg, Florian Umstätter, Cornelius Domhan, Tobias Hertlein, Knut Ohlsen, Andreas Krause, Ch… , 29 May 2020
In: Pharmaceuticals, ISSN 1424-8247. 13(2020,6) Artikel-Nummer 110, 14 Seiten
DOI: 10.3390/ph13060110 - Sauter, Max; Burhenne, Jürgen; Haefeli, Walter E.; Uhl, Philipp: An underestimated factor : the extent of cross-reactions modifying APIs in surface-modified liposomal preparations caused by comprised activated lipids / Max Sauter, Jürgen Burhenne, Walter E. Haefeli and Philipp Uhl, 27 September 2020
In: Molecules, ISSN 1420-3049. 25(2020,19) Artikel-Nummer 4436, 11 Seiten
DOI: 10.3390/molecules25194436 - Sauter, Max; Uhl, Philipp; Meid, Andreas; Mikus, Gerd; Burhenne, Jürgen; Haefeli, Walter E.: New insights into the pharmacokinetics of vancomycin after oral and intravenous administration : an investigation in beagle dogs / Max Sauter, Philipp Uhl, Andreas D. Meid, Gerd Mikus, Jürgen Burhenne, Walter E. Haefeli, 20 March 2020. - 5 S.
In: Journal of pharmaceutical sciences, ISSN 1520-6017. 109(2020), 6, Seite 2090-2094
DOI: 10.1016/j.xphs.2020.03.012 - Sauter, Max; Uhl, Philipp; Burhenne, Jürgen; Haefeli, Walter E.: Post-extraction disulfide bond cleavage for MS/MS quantification of collision-induced dissociation-resistant cystine-cyclized peptides and its application to the ultra-sensitive UPLC-MS/MS bioanalysis of octreotide in plasma / Max Sauter, Philipp Uhl, Jürgen Burhenne, Walter E. Haefeli, 10 April 2020. - 8 S.
In: Analytica chimica acta, ISSN 1873-4324. 1114(2020), Seite 42-49
DOI: 10.1016/j.aca.2020.04.016 - Sauter, Max; Uhl, Philipp; Burhenne, Jürgen; Haefeli, Walter E.: Ultra-sensitive bioanalysis of the therapeutic peptide exenatide for accurate pharmacokinetic analyses at effective plasma concentrations utilizing UPLC-MS/MS / Max Sauter, Philipp Uhl, Jürgen Burhenne, Walter E. Haefeli, 22 February 2020. - 7 S.
In: Journal of pharmaceutical analysis, ISSN 2214-0883. 10(2020), 3, Seite 233-239
DOI: 10.1016/j.jpha.2020.02.008 - Sauter, Max; Uhl, Philipp; Burhenne, Jürgen; Haefeli, Walter E.: Ultra-sensitive quantification of the therapeutic cyclic peptide bremelanotide utilizing UHPLC-MS/MS for evaluation of its oral plasma pharmacokinetics / Max Sauter, Philipp Uhl, Jürgen Burhenne, Walter E. Haefeli, 27 March 2020. - 6 S.
In: Journal of pharmaceutical and biomedical analysis, ISSN 1873-264X. 186(2020) Artikel-Nummer 113276, 6 Seiten
DOI: 10.1016/j.jpba.2020.113276 - Schuster, Lukas; Sauter, Max; Uhl, Philipp; Meid, Andreas; Haefeli, Walter E.; Weiß, Johanna; Theile, Dirk: Reporter cell assay-based functional quantification of TNF-α-antagonists in serum : a proof-of-principle study for adalimumab / Lukas Schuster, Max Sauter, Philipp Uhl, Andreas Meid, Walter E. Haefeli, Johanna Weiss, Dirk Theile, 26 February 2020. - 5 S.
In: Analytical biochemistry, ISSN 1096-0309. 596(2020) Arikel-Nummer 113646, 5 Seiten
DOI: 10.1016/j.ab.2020.113646 - Storck, Philip; Umstätter, Florian; Wohlfart, Sabrina; Domhan, Cornelius; Kleist, Christian; Werner, Julia; Brandenburg, Klaus; Zimmermann, Stefan; Haberkorn, Uwe; Mier, Walter; Uhl, Philipp: Fatty acid conjugation leads to length-dependent antimicrobial activity of a synthetic antibacterial peptide (Pep19-4LF) / Philip Storck, Florian Umstätter, Sabrina Wohlfart, Cornelius Domhan, Christian Kleist, Julia Werner… , 26 November 2020. - 12 S.
In: Antibiotics, ISSN 2079-6382. 9(2020), 12, Artikel-ID 844, Seite 1-12
DOI: 10.3390/antibiotics9120844 - Uhl, Philipp; Sauter, Max; Storck, Philip; Tursch, Anja; Özbek, Suat; Leotta, Karin; Fidelj, Veronika; Kleist, Christian; Fricker, Gert; Mier, Walter: Coating of PLA-nanoparticles with cyclic, arginine-rich cell penetrating peptides enables oral delivery of liraglutide / P. Uhl, PhD, C.Grundmann, M. Sauter, PhD, P. Storck, A. Tursch, S. Özbek, Prof, PhD, K. Leotta, R. R… , 2020. - 10 S.
In: Nanomedicine, ISSN 1549-9642. 24(2020) Artikel-Nummer 102132, 10 Seiten
DOI: 10.1016/j.nano.2019.102132 - Umstätter, Florian; Domhan, Cornelius; Hertlein, Tobias; Ohlsen, Knut; Mühlberg, Eric; Kleist, Christian; Zimmermann, Stefan; Beijer, Barbro; Klika, Karel D.; Haberkorn, Uwe; Mier, Walter; Uhl, Philipp: Überwindung von Vancomycinresistenzen durch Modifikation mit polykationischen Peptiden / Florian Umstätter, Cornelius Domhan, Tobias Hertlein, Knut Ohlsen, Eric Mühlberg, Christian Kleist, … , 2020. - 5 S.
In: Angewandte Chemie, ISSN 1521-3757. 132(2020), 23, Seite 8908-8912
DOI: 10.1002/ange.202002727 - Umstätter, Florian; Domhan, Cornelius; Hertlein, Tobias; Ohlsen, Knut; Mühlberg, Eric; Kleist, Christian; Zimmermann, Stefan; Beijer, Barbro; Klika, Karel D.; Haberkorn, Uwe; Mier, Walter; Uhl, Philipp: Überwindung von Vancomycinresistenzen durch Modifikation mit polykationischen Peptiden / F. Umstätter, C. Domhan, T. Hertlein, K. Ohlsen, E. Mühlberg, C. Kleist, S. Zimmermann, B. Beijer, K… , 2020. - 1 S.
In: Angewandte Chemie, ISSN 1521-3757. 132(2020), 40, Seite 17478
DOI: 10.1002/ange.202007022 - Umstätter, Florian; Domhan, Cornelius; Hertlein, Tobias; Ohlsen, Knut; Mühlberg, Eric; Kleist, Christian; Zimmermann, Stefan; Beijer, Barbro; Klika, Karel D.; Haberkorn, Uwe; Mier, Walter; Uhl, Philipp: Vancomycin resistance is overcome by conjugation of polycationic peptides / Florian Umstätter, Cornelius Domhan, Tobias Hertlein, Knut Ohlsen, Eric Mühlberg, Christian Kleist, … , 2020. - 5 S.
In: Angewandte Chemie, ISSN 1521-3773. 59(2020), 23, Seite 8823-8827
DOI: 10.1002/anie.202002727 - Umstätter, Florian; Domhan, Cornelius; Hertlein, Tobias; Ohlsen, Knut; Mühlberg, Eric; Kleist, Christian; Zimmermann, Stefan; Beijer, Barbro; Klika, Karel D.; Haberkorn, Uwe; Mier, Walter; Uhl, Philipp: Vancomycin resistance is overcome by conjugation of polycationic peptides / F. Umstätter, C. Domhan, T. Hertlein, K. Ohlsen, E. Mühlberg, C. Kleist, S. Zimmermann, B. Beijer, K… , 2020. - 1 S.
In: Angewandte Chemie, ISSN 1521-3773. 59(2020), 40, Seite 17326
DOI: 10.1002/anie.202007022 - Domhan, Cornelius; Uhl, Philipp; Kleist, Christian; Zimmermann, Stefan; Umstätter, Florian; Leotta, Karin; Mier, Walter; Wink, Michael: Replacement of L-amino acids by D-amino acids in the antimicrobial peptide ranalexin and its consequences for antimicrobial activity and biodistribution / Cornelius Domhan, Philipp Uhl, Christian Kleist, Stefan Zimmermann, Florian Umstätter, Karin Leotta,… , 17 August 2019
In: Molecules, ISSN 1420-3049. 24(2019,16) Artikel-Nummer 2987,12 Seiten
DOI: 10.3390/molecules24162987 - Mühlberg, Eric; Umstätter, Florian; Kleist, Christian; Domhan, Cornelius; Mier, Walter; Uhl, Philipp: Renaissance of vancomycin : approaches for breaking antibiotic resistance in multidrug-resistant bacteria / Eric Mühlberg, Florian Umstätter, Christian Kleist, Cornelius Domhan, Walter Mier, and Philipp Uhl, 2020. - 6 S.
In: Canadian journal of microbiology, ISSN 1480-3275. 66(2020), 1, Seite 11-16
DOI: 10.1139/cjm-2019-0309 - Sauter, Max; Uhl, Philipp; Majewsky, Marius; Fresnais, Margaux; Haefeli, Walter E.; Burhenne, Jürgen: An ultrasensitive UPLC-MS/MS assay for the quantification of the therapeutic peptide liraglutide in plasma to assess the oral and nasal bioavailability in beagle dogs / Max Sauter, Philipp Uhl, Marius Majewsky, Margaux Fresnais, Walter E Haefeli and Jürgen Burhenne, 16 May 2019. - 12 S.
In: Bioanalysis, ISSN 1757-6199. 11(2019), 9, Seite 887-898
DOI: 10.4155/bio-2018-0322 - Sauter, Max; Uhl, Philipp; Majewsky, Marius; Fresnais, Margaux; Haefeli, Walter E.; Burhenne, Jürgen: An ultrasensitive UPLC–MS/MS assay for the quantification of the therapeutic peptide liraglutide in plasma to assess the oral and nasal bioavailability in beagle dogs / Max Sauter, Philipp Uhl, Marius Majewsky, Margaux Fresnais, Walter E. Haefeli & Jürgen Burhenne. - Zweitveröffentlichung. -
London: Future Science, 2019. - 1 Online-Ressource (12 Seiten)
DOI: 10.11588/heidok.00028429 - Sauter, Max; Uhl, Philipp; Foerster, Kathrin; Mohr, Isabelle; Hoene, Rahel Thangam; Merle, Uta; Burhenne, Jürgen; Haefeli, Walter E.: An ultra-sensitive UHPLC-MS/MS assay for the quantification of orally administered vancomycin in plasma / Max Sauter, Philipp Uhl, Kathrin I. Foerster, Isabelle Mohr, Rahel T. Höne, Uta Merle, Jürgen Burhen… , 27 June 2019. - 6 S.
In: Journal of pharmaceutical and biomedical analysis, ISSN 1873-264X. 174(2019), Seite 633-638
DOI: 10.1016/j.jpba.2019.06.015 - Sieber, Sandro; Uhl, Philipp; Mier, Walter: Zebrafish as a predictive screening model to assess macrophage clearance of liposomes in vivo / Sandro Sieber, Philip Grossen, Philipp Uhl, Pascal Detampel, Walter Mier, Dominik Witzigmann, Jörg H… , 17 January 2019. - 12 S.
In: Nanomedicine, ISSN 1549-9642. 17(2019), Seite 82-93
DOI: 10.1016/j.nano.2018.11.017 - Witzigmann, Dominik; Uhl, Philipp; Kaufman, Christina; Schöneweis, Katrin; Ni, Yi; Mier, Walter; Urban, Stephan: Optimization-by-design of hepatotropic lipid nanoparticles targeting the sodium-taurocholate cotransporting polypeptide / Dominik Witzigmann, Philipp Uhl, Sandro Sieber, Christina Kaufman, Tomaz Einfalt, Katrin Schöneweis,… , 23 July 2019. - 28 S.
In: eLife, ISSN 2050-084X. 8(2019) Artikel-Nummer e42276, 28 Seiten
DOI: 10.7554/eLife.42276 - Domhan, Cornelius; Uhl, Philipp; Meinhardt, Anna; Zimmermann, Stefan; Kleist, Christian; Lindner, Thomas; Leotta, Karin; Mier, Walter; Wink, Michael: A novel tool against multiresistant bacterial pathogens : lipopeptide modification of the natural antimicrobial peptide ranalexin for enhanced antimicrobial activity and improved pharmacokinetics / Cornelius Domhan, Philipp Uhl, Anna Meinhardt, Stefan Zimmermann, Christian Kleist, Thomas Lindner, … , 2018. - 11 S.
In: International journal of antimicrobial agents, ISSN 1872-7913. 52(2018), 1, Seite 52-62
DOI: 10.1016/j.ijantimicag.2018.03.023 - Kruse, Sebastian; Büchler-Schäff, Marleen; Uhl, Philipp; Sauter, Max; Yang, Ruwen; Mier, Walter: Therapeutic vaccination using minimal HPV16 epitopes in a novel MHC-humanized murine HPV tumor model / Sebastian Kruse, Marleen Büchler, Philipp Uhl, Max Sauter, Philipp Scherer, Tammy C.T. Lan, Samantha… , 2019
In: OncoImmunology, ISSN 2162-402X. 8(2019,1) Artikel-Nummer e1524694, ? Seiten
DOI: 10.1080/2162402X.2018.1524694 - Uhl, Philipp; Pantze, Silvia; Storck, Philip; Parmentier, Johannes; Hofhaus, Götz; Mier, Walter; Fricker, Gert: Oral delivery of vancomycin by tetraether lipid liposomes / Philipp Uhl, Silvia Pantze, Philip Storck, Johannes Parmentier, Dominik Witzigmann, Götz Hofhaus, Jö… , 14 July 2017. - 8 S.
In: European journal of pharmaceutical sciences, ISSN 1879-0720. 108(2017), Seite 111-118
DOI: 10.1016/j.ejps.2017.07.013 - Uhl, Philipp: Orale Verfügbarkeit von Peptidwirkstoffen mittels liposomalen Formulierungen / vorgelegt von Apotheker Philipp Jonathan Uhl. -
Heidelberg, 2017. - xx, 111 Seiten : Illustrationen, Diagramme