Institute of Pharmacy and Molecular Biotechnology Department Pharmaceutical and Bioorganic Chemistry
Cellular significance of RNA and its modifications
The research group led by Prof. Dr. Andres Jäschke investigates unknown roles of RNA modifications, in particular of RNA-linked coenzymes, in biology. In addition, methods for imaging and microscopy of RNA in living cells and photoswitchable biomolecules are being developed. The group combines knowledge from organic synthesis with molecular and cell biology, biochemistry, bioinformatics and modern bioanalytical methods.
Research Topics
The research group investigates RNA modifications and their role in biology, develops methods for imaging RNA in living cells and works on photoswitchable biomolecules. One focus is on the discovery of new RNA modifications such as the linkage with the coenzyme NAD+. In addition, new imaging systems for RNA are being developed and photoswitchable compounds are being researched for applications in bionanotechnology. The research is funded by an ERC Advanced Grant and the German Research Foundation. In collaboration with other laboratories, the evolutionary development of the genetic code is also being investigated in order to generate experimental data and confirm theories.
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Information for Applicants
The Pharmaceutical and Bioorganic Chemistry group is open for Bachelor and Master theses. Applications are organized via the external page of the group. For inquiries, please contact Ms. Viola Funk.