Funktionelle Genomik Publikationen
2024
- Mao X, Gu H, Kim D, Kimura Y, Wang N, Xu E, Kumbhar R, Ming X, Wang H, Chen C, Zhang S, Jia C, Liu Y, Bian H, Karuppagounder SS, Akkentli F, Chen Q, Jia L, Hwang H, Lee SH, Ke X, Chang M, Li A, Yang J, Rastegar C, Sriparna M, Ge P, Brahmachari S, Kim S, Zhang S, Shimoda Y, Saar M, Liu H, Kweon SH, Ying M, Workman CJ, Vignali DAA, Muller UC, Liu C, Ko HS, Dawson VL, Dawson TM: Aplp1 interacts with Lag3 to facilitate transmission of pathologic α-synuclein
In: Nat Commun. 2024 May 31;15(1):4663.
- Bamford RA, Zuko A, Eve M, Sprengers JJ, Post H, Taggenbrock RLRE, Fäβler D, Mehr A, Jones OJR, Kudzinskas A, Gandawijaya J, Müller UC, Kas MJH, Burbach JPH, Oguro-Ando A: CNTN4 modulates neural elongation through interplay with APP In: Open Biol. 2024 May;14(5):240018.
- Buniatian GH, Schwinghammer U, Tremmel R, Cynis H, Weiss TS, Weiskirchen R, Lauschke VM, Youhanna S, Ramos I, Valcarcel M, Seferyan T, Rahfeld JU, Rieckmann V, Klein K, Buadze M, Weber V, Kolak V, Gebhardt R, Friedman SL, Müller UC,Schwab M, Danielyan L:Consequences of Amyloid-β Deficiency for the Liver. In: Advanced Science (Weinh). 2024 May;11(18):e2307734
- Mao X, Gu H, Kim D, Kimura Y, Wang N, Xu E, Kumbhar R, Ming X, Wang H, Chen C, Zhang S, Jia C, Liu Y, Bian H, Karuppagounder SS, Akkentli F, Chen Q, Jia L, Hwang H, Lee SH, Ke X, Chang M, Li A, Yang J, Rastegar C, Sriparna M, Ge P, Brahmachari S, Kim S, Zhang S, Shimoda Y, Saar M, Liu H, Kweon SH, Ying M, Workman CJ, Vignali DAA, Muller UC, Liu C, Ko HS, Dawson VL, Dawson TM: Aplp1 interacts with Lag3 to facilitate transmission of pathologic α-synuclein
In: Nat Commun. 2024 May 31;15(1):4663.
2023
- Shiraki Y., Mitsuma M., Takada R., Hata S., Kitamura A., Takada S., Kinjo M., Taru H., Muller UC, Yamamoto T., Sobu Y., and Suzuki T., Gupton S: Axonal transport of Frizzled5 by Alcadein α-containing vesicles is associated with kinesin-1
In: Molecular Biology of the CellVol. 34, No. 11
- Schilling S., August A., Meleux M, Conradt C., Tremmel L. M., Teigler S., Adam V.,Muller UC, Koo Edward H., Kins S. & Eggert S.; APP family member dimeric complexes are formed predominantly in synaptic compartments
In: Cell & Bioscience volume 13, Article number: 141 (2023)
- Lenz M., Eichler A., Kruse P., Galanis C., Kleidonas D., Andrieux G., Boerries M., Jedlicka P., Muller UC, Deller T. and Vlachos A.; The Amyloid Precursor Protein Regulates Synaptic Transmission at Medial Perforant Path Synapses
In: Journal of Neuroscience 19 July 2023, 43 (29) 5290-5304
- Danny Baltissen, Charlotte S. Bold, Lena Rehra, Marija Banićević, Justus Fricke, Jennifer Just, Susann Ludewig, Christian J. Buchholz, Martin Korte and Muller UC; APPsα rescues CDK5 and GSK3β dysregulation and restores normal spine density in Tau transgenic mice
In: Front. Cell. Neurosci., 26 January 2023 Sec. Cellular Neurophysiology; Volume 17 - 2023
2022
- Susanne Erdinger, Irmgard Amrein, Michaela Back, Susann Ludewig, Martin Korte, Jakob von Engelhardt, David P. Wolfer and Muller UC: Lack of APLP1 leads to subtle alterations in neuronal morphology but does not affect learning and memory
In: Front. Mol. Neurosci., 28 October 2022 Sec. Brain Disease Mechanisms Volume 15 - 2022
- Bold CS, Baltissen D, Ludewig S, Back MK, Just J, Kilian L, Erdinger S, Banicevic M, Rehra L, Almouhanna F, Nigri M, Wolfer DP, Spilger R, Rohr K, Kann O, Buchholz CJ, von Engelhardt J, Korte M, Muller UC: APPsα Rescues Tau-Induced Synaptic Pathology
In: J Neurosci. 2022 Jul 20;42(29):5782-5802.
- Tomàs Jordà-Siquier, Melina Petrel, Vladimir Kouskoff, Una Smailovic, Fabrice Cordelières, Susanne Frykman, Muller UC, Christophe Mulle, Gaël Barthet: APP accumulates with presynaptic proteins around amyloid plaques: A role for presynaptic mechanisms in Alzheimer's disease?
In: Alzheimer's & Dementia, Published 25 January 2022
2021
- Karen Arnaud, Vanessa Oliveira Moreira, Jean Vincent, Glenn Dallerac, Chantal Dubreuil, Edmond Dupont, Max Richter, Muller UC, Laure Rondi-Reig, Alain Prochiantz, Ariel A Di Nardo: Choroid plexus APP regulates adult brain proliferation and animal behavior
In: Life science alliance, Volume 4, No. 11, November 2021
- Naoto Oikawa, Marietta Fabiano, Muller UC, Jochen Walter : Carboxy-terminal fragment of amyloid precursor protein mediates lipid droplet accumulation upon γ-secretase inhibition
In: Biochem Biophys Res Commun. 2021 Jul 16;570:137-142
- Ludewig S, Herrmann U, Michaelsen-Preusse K, Metzdorf K, Just J, Bold C, Muller UC, Korte M. : Amyloid-Beta Mediates Homeostatic Synaptic Plasticity
In: Proc Natl Acad Sci U S A. 2021 Jun 29;118(26):e2011506118.
- Galanis C, Fellenz M, Becker D, Bold C, Lichtenthaler SF, Muller UC, Deller T, Vlachos A.: Amyloid-Beta Mediates Homeostatic Synaptic Plasticity
In: J Neurosci. 2021 Jun 16;41(24):5157-5172
DOI: 10.1523/JNEUROSCI.1820-20.2021. Epub 2021 Apr 29. PMID: 33926999
- Vicky Steubler, Susanne Erdinger, Michaela K Back, Susann Ludewig, Dominique Fässler, Max Richter, Kang Han, Lutz Slomianka, Irmgard, Amrein, Jakob von Engelhardt, David P Wolfer, Martin Korte, Muller UC: Loss of all three APP family members during development impairs synaptic function and plasticity, disrupts learning, and causes an autism-like phenotype
In: EMBO J (2021):e107471
2020
- Lauer AA, Mett J, Janitschke D, Thiel A, Stahlmann CP, Bachmann CM, Ritzmann F, Schrul B, Muller UC, Stein R, Riemenschneider M, Grimm HS, Hartmann T, Grimm MOW: Regulatory feedback cycle of the insulin‐degrading enzyme and the amyloid precursor protein intracellular domain: Implications for Alzheimer’s disease
In: Aging Cell. 2020;19:e13264.
- Mehr A, Hick M, Ludewig S, Müller M, Herrmann U, von Engelhardt J, Wolfer DP, Korte M, Muller UC: Lack of APP and APLP2 in GABAergic forebrain neurons impairs synaptic plasticity and cognition
In: Cereb Cortex 2020 Jun 1;30(7):4044-4063.
- Rice HC, Marcassa G, Chrysidou I, Horré K, Young-Pearse TL, Muller UC, Saito T, Saido TC, Vassar R, de Wit J, De Strooper B.M: Contribution of GABAergic interneurons to amyloid-β plaque pathology in an APP knock-in mouse model
In: Mol Neurodegener Jan 8;15(1):3.
2019
- Montagna E, Crux S, Luckner M, Herber J, Colombo AV, Marinković P, Tahirovic S, Lichtenthaler SF, Wanner G, Muller UC, Sgobio C, Herms J.,Glia: In vivo Ca2+ imaging of astrocytic microdomains reveals a critical role of the amyloid precursor protein for mitochondria
In: Epub 2019 Jan 22.
- Oikawa, N, Muller UC, Walter, J: Carboxy-terminal fragment of amyloid precursor protein mediates lipid droplet accumulation upon γ-secretase inhibition
In: Alzheimer's & Dementia THE JOURNAL OF THE ALZHEIMER'S ASSOCIATION
2018
- Herber J, Njavro J, Feederle R, Schepers U, Muller UC, Bräse S, Müller SA, Lichtenthaler SF: Click Chemistry-mediated Biotinylation Reveals a Function for the Protease BACE1 in Modulating the Neuronal Surface Glycoproteome
In: Mol Cell Proteomics. 2018 Aug;17(8):1487-1501.
- Barthet G, Jordà-Siquier T, Rumi-Masante J, Bernadou F, Muller UC & Mulle C: Presenilin-mediated cleavage of APP regulates synaptotagmin-7 and presynaptic plasticity
In: Nature Communications 9(1):4780
- Richter MC, Ludewig S, Winschel A, Abel T, Bold C, Salzburger LR, Klein S, Han K, Weyer SW, Fritz AK, Laube B, Wolfer DP, Buchholz CJ, Korte M, Muller UC : Distinct in vivo roles of secreted APP ectodomain variants APPsα and APPsβ in regulation of spine density, synaptic plasticity, and cognition
In: EMBO J. pii: e98335.
- Herber J, Njavro J, Feederle R, Schepers U, Muller UC, Bräse S, Müller S, Lichtenthaler SF : Click chemistry-mediated biotinylation reveals a function for the protease BACE1 in modulating the neuronal surface glycoproteome
In: Mol Cell Proteomics